The AcqKnowledge® Compliance and Resistance analysis is part of a suite of three automated respiration routines. The other two are Pulmonary Air Flow Analysis and Full Body Plethysmograph Penh. Each routine provides breath-by-breath analysis, event marking and exporting of the values to excel.
Compliance and Resistance
This analysis requires an air flow signal and a pressure signal. The analysis will extract compliance and resistance values along with many common pulmonary values. Pulmonary compliance is calculated using the isovolumetric method. A user specified percentage of the tidal volume is located on both sides of the tidal volume signal. Pulmonary resistance is defined as the difference in pressure divided by flow at these two points.
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Dynamic compliance is measured on a breath-by-breath basis by diving tidal volume by change in pressure between the exhale start and inhale start locations of the breath.
| Name | Abbrev. | Description | Units |
|---|---|---|---|
| Cycle | Index of the breath in the data, beginning at 1. | seconds | |
| Time | Starting time of the inhale of the breath. | ||
| Peak Inspiratory Flow | PIF | Maximum absolute flow occurring during the inhale portion of the breath. | liters/sec |
| Peak Expiratory Flow | PEF | Maximum absolute flow occurring during the exhale portion of the breath. | liters/sec |
| Tidal volume | TV | Total volume of air inhaled during the breath. | liters |
| Minute volume | MV | Volume of air that would be inspired during a minute given the tidal volume and breathing rate of this breath. TV * BPM | liters/ minute |
| Breaths per minute | BPM | Breathing rate. 60/TT | BPM |
| Inspiration time | IT | Time interval between the start of inhale and the start of exhale. | seconds |
| Exhalation time | ET | Time interval between the start of exhale and either: – start of apnea (if apnea present) – start of subsequent breath (if no apnea present) |
seconds |
| Total breath time | TT | Time interval between the start of inhale and the start of inhale of the following breath. This is the sum of the inhalation time, exhalation time, and apnea time. | seconds |
| Apnea time | AT | Time after end of exhalation where the airflow signal remained within the apnea threshold defined at the start of the analysis. | seconds |
| Pulmonary resistance | RES | Change in pressure divided by change in flow at the isometric volume locations: delta p/ delta f | mmHg/ (liters/ sec) |
| Pulmonary compliance | Cdyn | Tidal volume divided by the change in pressure between exhale and inhale locations in the breath: tv/delta p | liters/ mmHg |
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MP160 System
Wired | Compliance and Resistance Analysis
MP160 plus AcqKnowledge, transducer amplifiers, airflow transducer, pressure transducer, and sample accessories. Contact BIOPAC to discuss best options for pressure range and airflow accessories for your desired setup.
MP160 System
MP160 System
Animal | Compliance and Resistance Analysis
MP160 systems with AcqKnowledge plus transducer amps and pneumotach & differential pressure transducers
MP160 System
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