BIOPAC® Systems, Inc. Logo

198 – Prepulse Inhibition of Startle

A startle response is elicited by an intense stimulus with a sudden or abrupt onset such as the slamming of a door. The function of the startle response is to interrupt or disengage an organism from ongoing activity. The human startle response involves both somatic and cardiovascular components, seen in the form of a reflexive eye-blink or a whole-body jerk.

One method that is used in startle research involves the presentation of a weak, non-startling stimulus a brief time before the startle-eliciting stimulus. The weaker stimulus is called a prepulse or lead stimulus. Generally, this stimulus does not elicit a startle response. However, it can inhibit the response to a startle-eliciting stimulus, known as the prepulse inhibition of a startle effect (PPI). 

Associated Applications

Spotlight On
BIOPAC training

T4 Human Physiology Conference

Register Today! T4: Tools, Trends, Techniques, and Technology Monday, July 24, 2017 – Wednesday, July 26, 2017 Join BIOPAC for three days of hands-on, small-group human physiology workshops, presented by renowned experts, on the beautiful University of California at Santa Barbara campus in Santa Barbara, California, USA. Who should attend Anyone who records and analyzes […]

View All
Latest News

Mobita Advances Prestimulus EEG Research

The Mobita 32-Channel EEG recording system was used in research examining if physiological data can be used to predict truly random events that correspond to perceptual stimuli. Baumgart, et al. from the University of California Santa Barbara utilized a quantum random number generator (qRNG) to choose from three randomized conditions: light, sound, and no stimulus. […]

News Citations—Respiration and Cardiovascular Activity

BIOPAC provides software and hardware that allow for research teams to record and analyze respiration activity in physiological experimentation. Here are a few notable studies in monitoring respiration and cardiovascular activity. The coupling between peripheral microcirculation and slow breathing: The purpose of this study was to investigate the coupling of breathing movements and microcirculatory blood […]

Read All
Request a Demonstration
Request a Demonstration