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Baroreflex Sensitivity Analysis

Baroreflex Sensitivity (BRS) measures the relationship between blood pressure and heart rate. The body regulates blood pressure to ensure proper blood flow to organs underneath different conditions, e.g. supine to standing. Baroreflex sensitivity is a measure of how quickly the blood pressure system can compensate for changes in conditions. Variations in baroreflex sensitivity are useful as a comparative measure between subjects and for assessing various external impacts.

The Baroreflex Sensitivity (BRS) analysis license for AcqKnowledge provides two standard algorithms for deriving BRS from continuous noninvasive blood pressure and ECG. Two options are available, the slope method and the sequence method.

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Slope method:

This method operates over user selected  regions of data or the entire file. The routine identifies each ECG cycle and marks the components within the cycle (P,Q,R,S & T) and also locates and marks the systolic and diastolic points of the blood pressure signal. Systolic blood pressure values are plotted against the heart rate values in an interactive X/Y display that includes a table of values for each cycle. When a particular point is selected in the X/Y plot, the display highlights the data in the time series chart display.  Data points can be turned off and on  by selecting the X/Y points, or identifying them in the data table, and the slope of the best linear regression fit is updated to reflect the changes. The BRS value and goodness of fit value are also displayed and updated as data points are turned on and off.

AcqKnowledge Baroreflex Sensitivity - Slope Method

Sequence method:

This method operates over the entire file or within focus areas. The routine identifies each ECG cycle and marks the components within the cycle (P, Q, R, S & T) and also locates and marks the systolic and diastolic points of the blood pressure signal. There is an option for displaying the R-R values and systolic blood pressure values as new channels so that you can quickly identify outliers or noise in the raw data. The primary dialog includes settings for the minimum number of consecutive increasing or decreasing cycles and the minimum rate of change for heart rate (msec) and systolic blood pressure (mmHg) before a sequence is initiated.  The results of the analysis are displayed in the Journal or spreadsheet file.

References

  • Kuusela, Tom. On the Analysis of Baroreflex Sensitivity.  2010.
  • Patakas, D., Louridas, G. et. al.  Reduced baroreceptor sensitivity in patients with chronic obstructive pulmonary disease.  Thorax 1982; 37:292-295.
  • Reyes del Paso, Gustavo A.  A program to assess baroreceptor cardiac reflex function.  Behaviour Research Methods, Instruments & Computers.  1994, 26 (1), 62-64.

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