Compliance and Resistance Analysis

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The AcqKnowledge® Compliance and Resistance analysis is part of a suite of three automated respiration routines. The other two are Pulmonary Air Flow Analysis and Full Body Plethysmograph Penh. Each routine provides breath-by-breath analysis, event marking and exporting of the values to excel.

Compliance and Resistance

This analysis requires an air flow signal and a pressure signal. The analysis will extract compliance and resistance values along with many common pulmonary values. Pulmonary compliance is calculated using the isovolumetric method. A user specified percentage of the tidal volume is located on both sides of the tidal volume signal. Pulmonary resistance is defined as the difference in pressure divided by flow at these two points.

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Dynamic compliance is measured on a breath-by-breath basis by diving tidal volume by change in pressure between the exhale start and inhale start locations of the breath.

Name Abbrev. Description Units
Cycle Index of the breath in the data, beginning at 1. seconds
Time Starting time of the inhale of the breath.
Peak Inspiratory Flow PIF Maximum absolute flow occurring during the inhale portion of the breath. liters/sec
Peak Expiratory Flow PEF Maximum absolute flow occurring during the exhale portion of the breath. liters/sec
Tidal volume TV Total volume of air inhaled during the breath. liters
Minute volume MV Volume of air that would be inspired during a minute given the tidal volume and breathing rate of this breath. TV * BPM liters/
minute
Breaths per minute BPM Breathing rate. 60/TT BPM
Inspiration time IT Time interval between the start of inhale and the start of exhale. seconds
Exhalation time ET Time interval between the start of exhale and either:
– start of apnea (if apnea present)
– start of subsequent breath (if no apnea present)		 seconds
Total breath time TT Time interval between the start of inhale and the start of inhale of the following breath. This is the sum of the inhalation time, exhalation time, and apnea time. seconds
Apnea time AT Time after end of exhalation where the airflow signal remained within the apnea threshold defined at the start of the analysis. seconds
Pulmonary resistance RES Change in pressure divided by change in flow at the isometric volume locations: delta p/ delta f mmHg/
(liters/
sec)
Pulmonary compliance Cdyn Tidal volume divided by the change in pressure between exhale and inhale locations in the breath: tv/delta p liters/
mmHg

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Hardware Packages   |   Compliance and Resistance Analysis

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Wired

MP160 System for airflow measurements

  • 1 x MP160 Data Acquisition Systems
  • 2 x General Purpose Transducer Amplifier
  • 1 x Medium Flow Trans 300 L/min
  • 1 x Disposable Facemask
  • 1 x Differential Pressure Transducers

Animal

MP160 System + Transducer amps & Pneumotach & Pressure transducers

  • 1 x MP160 Data Acquisition Systems
  • 1 x Animal Pneumotachs 17 ml/sec-1.7 L/sec
  • 1 x Differential Pressure Transducers
  • 1 x General Purpose Transducer Amplifier

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